From: Inflammatory pseudotumor-like follicular dendritic cell tumor: an underdiagnosed neoplasia
Mean age (y) M:F ratio | Symptoms | Preferred sites | Markers | Clinical outcome |
---|---|---|---|---|
Inflammatory pseudotumor | ||||
Middle age to elderly; no gender predilection reported for lymph node; 5:3 female predominance for splenic cases (Ma et al., 2013) | Variable: no symptoms; previous signs of infectious process; presence of general symptoms (ca. 60%) | Lymph nodes and spleen more common; may be extranodal | May be positive: CD68, smooth muscle actin; Negative: ALK and dendritic cell markers; microorganisms may be found (mycobacteria, lues, fungi, EBV more frequent in spleen and liver) | Favorable after treatment; no recurrence or distant metastases |
Inflammatory myofibroblastic tumor | ||||
Around 30 years; Children and young adults preferred; M equal to F | 15–30% general symptoms: fever, weight loss, anemia, thrombocytosis, hipergammaglobulinemia, elevated erythrocyte sedimentation rate | Lung, soft tissue of abdomen, pelvis and retroperitoneum | Spindle cells frequently positive for smooth muscle actin; ALK positive ~50–60%; May be EBV+; Negative for CD21, CD23, CD35, CNA42 | Local recurrence (10–25%); distant metastases (<5%) |
Inflammatory pseudotumor-like follicular dendritic cell tumor | ||||
Around 40y;Female predominate | Assymptomatic, abdominal pain, fadigue | Spleen, liver or both | Positive for CD21, CD23, CD35, CNA42; Negative for ALK; EBV+ | Local recurrence and distant metastases less frequent than other FDCT (>40% recurrence and >25% metastases lung, lymph node, liver) |