Table 3 Shows a comparison of the dosage used, the number of cycles and reported survival of landmark studies and this study
Drugs/cycles | This study (Median dose) | EXTREME regimen [7] | TPEx regimen [11] | TPF regimen [10] | PCE regimen [14] | SPECTRUM regimen [5] |
|---|---|---|---|---|---|---|
Paclitaxel mg/m2 | 80 | Â | Â | Â | 100 | Â |
Docetaxel mg/m2 | 32.5 | Â | 75 | 75 | Â | Â |
CISplatin mg/m2 | 45 | 100 | 75 | 75 | Â | 100 |
CARBOplatin AUC | 3 | 5 | Â | Â | 2.5 | Â |
5FU mg/m2/day | 360 | 1000 | Â | 750 | Â | 1000 |
Cetuximab mg/m2 | 250 | 250 | 250 | Â | 250 | Â |
Panitumumab mg/kg | 3.5 | Â | Â | Â | Â | 9 |
Maximum cycles | 14 (median 9) | 6 | 4 | 4 | 6 | 6 |
PFS (months) | 14.0 (CI: 5.3,22.6) | 5.6 | 14 | 11 | 5.2 | 5.8 |
OS (months) | 15.7 (CI: 1.7, 29.7) | 10.1 | 6.2 | 18.8 | 14.7 | 11.1 |