Fig. 5From: What is new in Genitourinary Pathology? Recent developments and highlights of the new 2016 World Health Organization classification of tumors of the urinary system and male genital organs a GCNIS is a proliferation of intratubular malignant germ cells with morphologic and immunohistochemical features of seminoma cells arising in the spermatogonial niche; note also the presence of intertubular infiltrating seminoma. b IHC by C-kit (CD117) highlights the GCNIS in the tubules and in the interstitiumBack to article page